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MK2 inhibitor III
CAS No. 1186648-22-5
MK2 inhibitor III( —— )
Catalog No. M10637 CAS No. 1186648-22-5
A potent, cell-permeable inhibitor of MK2 with IC50 of 8.5 nM; less potently blocks MK3 and MK5 (IC50s=210 and 81 nM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 147 | Get Quote |
|
| 10MG | 237 | Get Quote |
|
| 25MG | 475 | Get Quote |
|
| 50MG | 692 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 500MG | 1944 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMK2 inhibitor III
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, cell-permeable inhibitor of MK2 with IC50 of 8.5 nM; less potently blocks MK3 and MK5 (IC50s=210 and 81 nM, respectively).
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DescriptionA potent, cell-permeable inhibitor of MK2 with IC50 of 8.5 nM; less potently blocks MK3 and MK5 (IC50s=210 and 81 nM, respectively) and is weak or inactive against several other kinases, including P38 MAPKs; prevents LPS-induced synthesis of TNF-α in human monocyte-like U937 cells with IC50 of 4.4 uM.
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In VitroMK2-IN-3 hydrate suppresses TNFα production in U397 cells with an IC50 of 4.4 μM.
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetMAPKAPK2 (MK2)
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RecptorMAPKAPK2 (MK2)
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Research Area——
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Indication——
Chemical Information
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CAS Number1186648-22-5
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Formula Weight358.4
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Molecular FormulaC21H16N4O ? H2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (348.78 mM)
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SMILESC1CNC(=O)C2=C1NC(=C2)C3=CC(=NC=C3)C4=CC5=CC=CC=C5N=C4.O
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Chemical Name2-(2-(quinolin-3-yl)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one hydrate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Anderson DR, et al. J Med Chem. 2007 May 31;50(11):2647-54.
2. Gurgis F, et al. Cell Death Discov. 2015 Sep 7;1:15028.
molnova catalog
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